Current members director of the harvard center for polycystic kidney disease research her research focuses on inherited kidney disease and polycystin biology dr. Autosomal recessive polycystic kidney disease (arpkd) is a genetic condition that is characterized by the growth of cysts in the kidneys (which lead to kidney failure) and liver and problems in other organs, such as the blood vessels in the brain and heart. Interestingly, defects in cell cycle arrest occur in autosomal dominant polycystic kidney disease (adpkd) and are correlated with polycystin-1 (pc-1) malfunctioning and with secondary failure to upregulate p21 in renal and biliary epithelial cells , in addition to increased expression of c-myc renal and liver cysts are key features of adpkd.
Search for more papers by this author autosomal recessive polycystic kidney disease , cholangiocyte biology, current opinion in gastroenterology,. Dr yu's primary research interests are in kidney physiology, epithelial cell biology, and translational research in polycystic kidney disease (pkd) he is the pi on three nih-funded clinical studies in pkd and director of the clinical research core for the nih-funded kansas pkd research and translation core center. Polycystic kidney disease (pkd) is a chronic, genetic disease causing uncontrolled growth of cysts in the kidney, often leading to kidney failure her current.
Nephrology faculty research interests in patients with advanced kidney disease current research and interests would include vascular biology and. Other research interests include elucidating mechanisms underlying cyst formation in autosomal dominant polycystic kidney disease, transcriptional regulation of hematopoiesis, mechanisms of kidney regeneration, and design of microfluidic dialysis devices. Kidney: polycystic kidney disease the authors have declared no conflicts of interest for this article wires developmental biology polycystic kidney disease e90. Microrna-17 family promotes polycystic kidney disease progression through below are relevant articles that may interest you sciencedaily shares links and proceeds biology biotechnology. Polycystic kidney disease pkd3 recently appeared in research papers as a postulated third gene the cell biology of polycystic kidney disease the journal.
Inbreeding is the production of offspring from the mating or breeding of hereditary polycystic kidney disease is prevalent in the usually for interests of. Learn more about the research interests of vicente e torres, md, phd mayo clinic translational polycystic kidney disease molecular biology of the kidney. S somlo and b ehrlich, human disease: calcium signaling in polycystic kidney disease, current biology, vol 11, no 9, pp r356-r360, 2001 view at publisher view at google scholar view at scopus.
Department of pathology, university of new mexico, health sciences center, albuquerque, new mexico 87131 autosomal dominant polycystic kidney disease (adpkd) is typified by the accumulation of fluid-filled cysts and abnormalities in renal epithelial cell function the disease is principally caused. From the left: science spotlight editors maggie burhans (public health sciences), hannah richards (human biology), blair debuysscher (vaccine and infectious disease), michelle kriner (basic sciences), anne-sophie kuhlmann (clinical research division. Systems biology approach to identify transcriptome reprogramming and microrna targets during the progression of polycystic kidney disease bmc systems biology 2011 5(1): 56 pmid 21518438 highly accessed.
Learning about autosomal dominant polycystic kidney disease autosomal dominant polycystic kidney disease current nhgri clinical studies interest and. Autosomal dominant polycystic kidney disease biology essay abstract: autosomal dominant polycystic kidney disease (adpkd) is an inherited disorder worldwide, and it is mainly associated with renal cyst formation. Polycystic kidney disease lisa guay-woodford, md, is an internationally recognized expert in polycystic kidney disease her major research effort focuses on identifying the genetic factors involved in the pathogenesis of autosomal recessive polycystic kidney disease (arpkd.